Akasha was once the queen of the Nile (she has a bit in common with the Egyptian goddess Isis), and it's unwise to rile her now that she's had 60 centuries of practice being undead. She is so peeved about male violence that she might just have to kill most of them. And she has her eye on handsome Lestat with other ideas as well.
The same two gay male vampires, Louis and Lestat, who were in 'Interview with the Vampire' and 'The Vampire Lestat'. Worth reading if you've read the previous two.